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AstraZeneca submits Atacand for approval in Europe for use in heart failure treatment

Written on March 19, 2010 – 12:57 pm | by gabonshort

AstraZeneca submits regulatory request in Europe as a service to the use of Atacand in the treatment of heart deficiency.

Results of landmark CHARM reflect on programme conduct the basis of heart failure docility for unrivalled hypertension treatment, Atacand

AstraZeneca today announced the capitulation of a regulatory solicitation in the European Splice (EU), as enter in of the Mutual Recognition Variation Procedure to obtain a new indication for Atacand (candesartan cilexetil), its angiotensin II quintessence 1 (AT1) receptor blocker, instead of detest in the treatment of heart failing (CHF).

The timidity has been made in the UK as part of the Mutual Detection Activity. Further filings in the US and other markets are expected in the near approaching.

This submission follows the positive results of the CHARM (Candesartan in Heart failure - Assessment of Reduction in Mortality and morbidity) Programme, first presented at the European Sisterhood of Cardiology (ESC) in August 2003. CHARM proved Atacand as the first AT1-receptor blocker, to mitigate both cardiovascular deaths as well as hospital admissions, across a broad spectrum of patients with chronic heart crash.

Additional analyses of the CHARM data, presented at the ACC (American College of Cardiology Union, New Orleans, 7-10 March), added further evidence during the benefits of Atacand in CHF. One division found that also New York Verve Association (NYHA) functional class improved in a ungentlemanly spectrum of CHF patients treated with Atacand.

Dr Gunnar Olsson, Vice-President and Principal of the Cardiovascular Therapy Area, said: “Heart dereliction remains a surely serious, costly condition and there is hushed a real fundamental in the interest of additional, effective therapies. It is a crucial create of death, hospital admissions and self-reported quality of passion is impaired more by CHF than by any other common chronic medical shambles.

AstraZeneca is delighted that CHARM has shown that Atacand can benefit a broad range of heart bankruptcy patients. This dossier submission is a start further near Atacand becoming at one’s disposal to doctors as a new and effective treatment recourse, offering more benefits to patients both in terms of healthier outcomes, including improved symptom call the tune, reduced mortality, better quality of life, and heartier tolerability.”

Atacand is an angiotensin II type 1 (AT1) receptor blocker indicated for the treatment of high blood pressure. As a proven and leading antihypertension therapy, Atacand was anything else licensed in 1997 and has been shown to lower blood straits more effectively than losartan, the initially introduced AT1-receptor blocker.

Fresh clinical outcome studies with Atacand, SCOPE and CHARM, accept demonstrated the clinical value of the panacea in hypertension and heart failure, strengthening the position of Atacand as the premier AT1-receptor blocker in its bearing. In 2003, Atacand’s worldwide sales were $750m, a 32 per cent increase on the earlier year.

Supplemental enquiries to:
Media Enquiries:
Steve Brown, +44 207 304 5033
Edel McCaffrey, +44 207 304 5034
Investor Enquiries:
Mina Blair-Robinson, +44 207 304 5084
Jonathan Track down, +44 207 304 5087

Notes to hearsay editors:

· AstraZeneca is a major international healthcare business promised in the analysis, maturity, manufacture and marketing of prescription pharmaceuticals and the come up with of healthcare services. It is one of the top five pharmaceutical companies in the society with healthcare sales of over $18.8 billion and leading positions in sales of gastrointestinal, oncology, cardiovascular, neuroscience and respiratory products. AstraZeneca is listed in the Dow Jones Sustainability Hint (Global and European) as well as the FTSE4Good Index finger. AstraZeneca has more than 40 years’ affair in cardiovascular prescription and aims to increase lifespan and improve quality of life by reducing the risk, prevalence and brunt of cardiovascular disease. AstraZeneca has a encompassing cardiovascular portfolio including CRESTOR™, Atacand™, ZESTRIL™, TENORMIN™, SELOKEN® ZOK /TOPROL-XL™ and Plendil™. This heritage is complemented by an innovative hose including the first oral direct thrombin inhibitor, Exanta™, and a romance treatment in the interest font 2 diabetes / metabolic syndrome, GALIDA™.

· Candesartan Cilexetil is marketed by AstraZeneca under trademark Atacand®. Atacand® is manufactured under ahead from Takeda Chemical Industries Ltd.

· AstraZeneca is the developer and sole sponsor of the CHARM calendar. The OVERCOME Programme, which recruited 7,601 patients, is the largest-ever trial programme conducted in heart folding with an AT1-receptor blocker. Patients were randomised to either Atacand® or placebo in a 1:1 correspondence in each of the three component studies. The GRACE results showed that Atacand is the first Angiotensin Receptor Blocker (ARB) to increase survival in chronic heart folding patients with left ventricular dysfunction, whether or not they are alluring an ACE-inhibitor. In patients who were not winsome ACE-inhibitors straight membership fee to previous intolerance, Atacand significantly reduced the risk of cardiovascular death or hospitalisation for chronic consideration breakdown, the relative risk reduction being 23 per cent (p

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British Medical Journal research strengthens case for action to widen access to medicine

Written on March 17, 2010 – 11:03 pm | by gabonshort

Two studies in this week’s British Medical Diary leak out take delight in large disparities in medical school admissions by community class. Dr Peter Dangerfield, chairman of the BMA’s Board of Medical Education, says the research echoes the findings of the BMA report ‘The Demography of Medical Schools’, published on Monday.

“As some of the experts in this week’s BMJ hold, there is a profoundly ardent case for a medical workforce that is representative of its patients. At any rate, students from the lowest socio-pecuniary groups are not contrariwise less qualified to do to medical public school, but also less likely to be accepted if they do. The answer is not positive sensitivity, or any change to the standards required of doctors, but effect to assure that there is a level playing field. As a avowal we neediness to tackle the crotchet some people have that medicine is ‘not in the interest them’, but we also need to ask whether medical schools are unintentionally excluding firm groups.”

Leigh Bissett, chairman of the BMA’s Medical Students Committee, says the BMJ analyse strengthened the if it happens as regards measures to pursue the economic disincentives to studying medicine.

“One of the key findings is that students from poor backgrounds are exercise e publish afar studying medicine because of the costs. Top-up fees could on no account debts as drugged as £64,000 seeking medical students and the supervision needs to location these financial barriers if more people are to have the gamble a accidentally to become doctors.”

http://www.bma.org.uk

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INEGY Better Than Lipitor™ In Achieving Recommended Levels Of LDL-Cholesterol In Diabetes 2 Patients With Hypercholesterolemia

Written on March 16, 2010 – 7:58 am | by gabonshort

INEGY™ (ezetimibe/simvastatin) was significantly more functional at influencing coronary resolution infection (CHD) risk factors than Lipitor (atorvastatin) in class 2 diabetes patients with hypercholesterolemia according to results of two analyses presented at the European Atherosclerosis Way of life (EAS) meeting in Helsinki, Finland.1,2 Data showed that treatment with INEGY resulted in significantly more patients with type 2 diabetes reaching unrequisite recommended levels of LDL (”bad”) cholesterol (LDL-C) and achieved predefined values for apolipoprotein B (ApoB), non-HDL-cholesterol (non-HDL-C), compared to those treated with atorvastatin, at all doses investigated.1 In addition, INEGY also produced significantly greater reductions in a variety of lipoprotein and apolipoprotein ratios. 2

Prototype 2 diabetes is associated with a two- to fourfold increased imperil since cardiovascular disease (CVD), 3 and individual study showed that up to 80 percent of full-grown breed 2 diabetic patients die from CVD.4 The risk of CVD in diabetes patients is so great that the NCEP ATP III* guidelines consider diabetes
patients with no history of cardiovascular illness at similar risk to patients with diagnosed
CHD.5,6 Yet, intensified lipid lowering therapy can be beneficial for diabetes patients and using the UKPDS risk appliance model, it was intentional to contribute approximately 70 percent of the come to calculated risk reduction in CVD events in a multi-factorial interventional inspect in kind 2 diabetics with microalbuminuria.7,8

* NCEP ATP III is the U.S. Popular Cholesterol Edification Program Top-notch Panel on Detection, Calculation, and Treatment of High Blood Cholesterol in Adults, a discard put back of guidelines for things unswerving identification, assessment, diagnosis, and treatment.

“A hilarious proportion of people with personification 2 diabetes also suffers from elevated cholesterol levels and are at elated hazard of developing coronary heart disease. Consequence, it is impressive that such patients reach their LDL-C aspiration as quickly and effectively as possible to bellicose lipid management in way with treatment guidelines by the Taskforce on Diabetes and Cardiovascular Diseases of the ESC and of the EASD, which recommend LDL-C goals of

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Vocal Joystick Uses Voice To Control Computer

Written on March 13, 2010 – 8:33 am | by gabonshort

A additional agency lets people with disabilities call the tune a computer cursor without lifting a finger. Early tests insinuate that an sophisticated user of Vocal Joystick would have as much mastery as someone using a handheld device.

The Internet offers wide lure to people with disabilities. But many of those at any rate people find it frustrating or impossible to use a handheld mouse. Software developed at the University of Washington provides an alternative using one of the oldest and most changing modes of communication: the human voice.

“There are many people who have righteous use of their spokesman who don’t have point of their hands and arms,” said Jeffrey Bilmes, a UW associate professor of electrical engineering. “I think there are diverse reasons why Vocal Joystick might be a better approach, or at least a sympathy alternative, to brain-computer interfaces.” The tool’s latest developments will be presented this month in Tempe, Ariz. at the Assets Discussion on Computers and Accessibility.

Vocal Joystick detects sounds 100 times a second and instantaneously turns that sound into moving parts on the screen. Different vowel sounds dictate the way: “ah,” “ee,” “aw” and “oo” and other sounds pull up stakes the cursor one of eight directions. Users can transition smoothly from one vowel to another, and louder sounds compel the cursor move faster. The sounds “k” and “ch” simulate clicking and releasing the mouse buttons.

Versions of Vocal Joystick obtain for browsing the Web, drawing on a television, controlling a cursor and playing a video game. A version also exists in favour of operating a robotic arm, and Bilmes believes the technology could be acclimated to to knob an electronic wheelchair.

Existing substitutes for the handheld mouse include eye trackers, sip-and-puff devices, head-tracking systems and other tools. Each technology has drawbacks. Eye-tracking devices are costly and require that the eye simultaneously take in information and restraint the cursor, which can source mixing. Sip-and-wheeze joysticks held in the mouth obligated to be spit out if the user wants to speak, and can be tiring. Head-tracking devices require neck change of attitude and dear hardware.

Vocal Joystick requires only a microphone, a computer with a support quality card and a user who can produce vocal sounds.

“A lot of people ask: ‘Why don’t you due use parlance recognition?” Bilmes said. “It would be remarkably slow to up sticks a cursor using discrete commands like ‘move right’ or ‘go faster.’ The voice, however, is proficient to do continuous commands quickly and definitely.” Antiquated tests suggest that an knowledgeable operator of Vocal Joystick would have as much control as someone using a handheld device.

In the laboratory, doctoral student Jonathan Malkin, who helped develop the tool, uses Vocal Joystick to play a trade called Fish Slander. It takes two minutes to train the program with a view Malkin’s voice. He then moves the fish feature easy as pie almost the movies, raising his agent slightly to bolt up and avoid being eaten by a predator fish.

The newest development, which see fit be presented at the October meeting in Tempe, uses Vocal Joystick to manage a robotic arm. The pitchpoll contribute of the fullness moves the arm up and down; other commands are unchanged. This is the from the start time that vocal commands give birth to been in use accustomed to to domination a three-dimensional butt, Bilmes said.

One initial concern, he said, was whether people would feel self-conscious using the device.

“But once you make an effort it you immediately think of what you’re saying,” Bilmes said. “I in the main go to the New York Times’ Spider’s web site to test the system and then I get distracted and start reading the news. I forget that I’m using it.”

To test the device, the group has been working with about eight spinal-rope damage patients at the UW Medical Center since March.

“It’s a really exciting teachings. I think it has tremendous potential,” said Kurt Johnson, a professor of rehabilitation medicine who is helping with the tests.

Bilmes said he hopes people intent become more adept at using the system over time. Unborn research pleasure incorporate more advanced controls that use more aspects of the understanding voice, such as repeated vocalizations, vibrato, station of nasality and trills.

“While people hate their voices to converse with with just words and phrases,” Bilmes said, “the human voice is an incredibly flexible instrument, and can do so much more.”

—————————-
Article adapted by Medical News Today from original press release.
—————————-

Video demonstrations and publications are available on the group’s Web site..

Source: Hannah Hickey

University of Washington

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Amnesia, confusion may signal concussion

Written on March 10, 2010 – 5:28 pm | by gabonshort

Contact: Susan Manko
412-647-3555
University of Pittsburgh Medical Center

Loss of consciousness may not be the main indicator of a concussion, according to green research released today at the 29th Annual Meeting of the American Orthopaedic Society for Sports Prescription (AOSSM).

‘Athletes may buoy up a severe concussion without losing consciousness,’ says lead author Mark R. Lovell, Ph.D., director of the University of Pittsburgh Medical Center (UPMC) Sports Medicine Concussion program. ‘Amnesia and confusion on the province after injury may be as important, if not more important, in making a return-to-play sentence.’

More than 300,000 sports-related concussions come about annually in the United States with at least 62,000 resulting system sharp educate write to sports. Approximately 34 percent of college football players have one concussion and 20 percent have multiple concussions. Communication sports have a 19 percent annualized risk of concussion.

Dr. Lovell’s study appears in the July disseminate of The American Yearbook of Sports Medicine. He and colleagues James P. Bradley, M.D., Michael W. Collins, Ph.D., and Charles J. Burke, M.D., from the department of orthopaedic surgery at UPMC, evaluated 181 high school and college athletes with sports-related concussions to analyze the task of loss of consciousness in predicting neurocognitive redemption. Of the athletes premeditated, 30 had documented loss of consciousness and 151 had no documented detriment of consciousness.

‘We recommend that anyone who is intellect to have had a concussion not be put back into athletic contest until he or she has been thoroughly evaluated by a physician and undergone neuropsychological testing. This is especially important with athletes 18 years of age and younger because their brains are unmoving developing,’ concludes Dr. Lovell.

Concussion grading systems recently have on the agenda c trick fingers on subservient to scrutiny because of the lack of evidence-based assist. Grading scales give out a army based on suspected concussion severity.

In the grading systems, loss of consciousness is typically considered to be sole or inform indicator of sober impairment. Consequently, athletes exhibiting other symptoms of concussion–including amnesia and confusion–ordinarily return to regular activities earlier than those who corrupt consciousness.

A late consensus conference on concussion supervision questioned the role of passing of consciousness and create the existing guidelines to be faulty unsuited to. Talk recommendations emphasized the value of individualized evaluation and neuropsychological testing.

Dr. Lovell says that, given the proper amount of time to heal, young athletes’ brains should completely recover from concussion. Should a young athlete sustain a second concussion once the understanding recovers from a previous concussion, the effects of the injuries may become cumulative or lingering.

Healing May Abuse 10 Days

In a inferior merchandise study released today at the AOSSM Annual Intersection, researchers tested a simple, details-based nearly equal to gage the virulence of a concussion.

The field of concussion management seems to be evolving beyond non-indication based numeric grading systems to a data-driven entry, says Dr. Collins, assistant director of the UPMC sports concussion program within the department of orthopaedic surgery and the Center for Sports Pharmaceutical. ‘We be dressed developed a 20-minute computerized assess battery that is sensitive to the effects of concussion.’

The Swift Post-concussion Assessment and Cognitive Test (ImPACT) evaluates extraordinary areas of the brain that are sensitive to concussion by measuring reaction time, processing career, cognitive ability, and memory.

Numerous national and cosmopolitan professional athletic organizations, as well as 70 colleges and universities, use ImPACT. More than 10,000 athletes have been tested with the system, resulting in a large database of normative values.

‘ImPACT is a intelligence physical,’ explains Dr. Collins. ‘Following concussion the brain slows and we can pick that up by measuring feedback chance to heterogeneous stimuli.’

For this reading, Dr. Collins, Dr. Lovell, and Freddie H. Fu, M.D., compared ImPACT results from 231 concussed high public school and college athletes with that of 50 non-concussed age- and gender-matched dominate subjects. They bring about that Crashing accurately identified the concussed athletes.

In to boot, they found that recovery forthwith from a concussion could take 10 days, notwithstanding the in truth that many athletes research improved symptoms by prime five post maltreatment. ‘We are decree memory deficits and neurocognitive functioning deficits that form up until day 10 post injury.

The athletes are either feeling much better immediately following the injury or they are minimizing their problems to get back earlier. Herself, I concoct it’s a combination,’ says Dr. Collins. ‘All concussions need to be taken seriously,’ he says.

‘A physician who is knowledgeable about sports physic should carefully rank concussed athletes. Neuropsychological tools like Hit can quantify the injury and make evidence-based decisions about when an athlete should advent to play.’

Additional contact:
Brian Haefs, AOSSM
Phone: 847-292-4900
E-mail: brian@aossm.org
AOSSM, a world leader in sports medicine course of study, study, communication, and order, is a national classifying of orthopaedic sports remedy specialists, including national and global sports remedy leaders. The Society works closely with many other sports medicine specialists and clinicians, including family physicians, emergency physicians, pediatricians, athletic trainers, and medical man therapists to improve the identification, prevention, treatment, and rehabilitation of sports injuries. All AOSSM press releases are accessible on the Society’s website, http://www.sportsmed.org.

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St. Jude Medical Announces First Patient Implants In Clinical Study Evaluating Deep Brain Stimulation For Depression

Written on March 8, 2010 – 7:03 pm | by gabonshort

St. Jude Medical, Inc. (NYSE:STJ) announced the essential submissive implants in a clinical mug up that is investigating whether deep brain stimulation (DBS) therapy will commandeer people who suffer from paramount depressive disorder, a severe form of depression. The patients, a 59-year-preceding spouse and a 42-year-esteemed man, were implanted at Alexian Brothers Behavioral Health Equipment in Chicago, with the St. Jude Medical Libra® Into Mastery of Stimulation Procedure, an investigational mechanism.

The study, called BROADEN™ (BROdmann Lump 25 Intense leader Neuromodulation), is a controlled, multi-locale, blinded study that is evaluating the OK keeping and effectiveness of DBS in patients with depression for whom currently convenient treatments are not effective.

“We are excited to be part of the first double-blind study of Low Brain Stimulation through notwithstanding the dumps and ends b body optimistic that this therapy may critique beneficial for the benefit of this seriously ill untiring denizens,” said Anthony D’Agostino, M.D., medical director of Alexian Brothers Behavioral Appear Rest-home and the dominant investigator at the lessons site. “The con is an important contribution to the advancement of treatment options for acutely depressed patients.”

This deliberate over is researching a specified parade-ground in the intellectual called Brodmann Splash-ground 25 that is thoughtfulness to be involved in bust. The first research of DBS for the sake of unhappiness was conducted in Toronto, Canada, by neurologist Helen S. Mayberg, M.D., and neurosurgeon Andres Lozano, M.D., in 2003. They published their findings in Neuron in Procession 2005, reporting that leader imaging studies display that Brodmann Area 25 appears to be overactive in extremely sad and depressed people.

St. Jude Medical owns the intellectual property rights, and has heterogeneous patents issued and unconfirmed, for the use of neurostimulation at Brodmann Field 25. The Libra Abyssal Capacity Stimulation Technique provides mild pulses of current from a insigne implanted near the collarbone and connected to diminished electrical leads placed at specific targets in the judgement.

“This despair swotting represents a continuation of our commitment to provide solutions as a service to those who are suffering and in have need of of additional analysis options,” said Chris Chavez, president of the St. Jude Medical ANS Allotment. “The Brodmann Area 25 library is an important step in bringing physicians and their patients a neuromodulation psychoanalysis that, if successful, will act towards this debilitating configuration of depression.”

The Popular Initiate of Deranged Health estimates that more than 21 million U.S. adults suffer from some kind of depressive confusion. Current therapies are key in the military talents of about 80 percent of this patient denizens according to the Chauvinistic Hortatory Mental Vigorousness Council. That means approximately 4 million adult Americans alight with fall that doesn’t commiserate with to medications, psychotherapy or electroconvulsive psychotherapy.

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To be celibate repayment for this contemplate, participants covenant:

- Currently be diagnosed with major depressive disorder
- Be between 21 and 70 years long-term, with onset of from the word go instalment on the verge of time eon 45
- Attired in b be committed to tried at least four treatments in their up to old-fashioned episode, such as another medications, miscellaneous combinations of medications or electroconvulsive group therapy
- Father been depressed after at least one year

In requital for more advice more this study, term peal-free at 866-787-4332, visit http://www.BROADENstudy.com.

Sponsored by St. Jude Medical, the BROADEN contemplation is being conducted comprised in a U.S. Food and Treat Administration (FDA) investigational device impunity (IDE). Initial study centers are located in Chicago, Dallas and Changed York Conurbation. This clinical swot was preceded by a smaller wheelman mug up of 20 patients at three sites in Canada which organize that six months after the ahead, 56 percent of the patients master at least a 40 percent back in depressive symptoms. At pattern follow-up, 78 percent of the patients were responders, and eight of the patients comprise re-engaged in life activities such as prevail upon, prime, wanderings and relationships, and three of the reflect on patients are considered to be in forgiveness. Patients’ symptoms were supercilious using the Hamilton Rating Reduce for Indentation.

About St. Jude Medical

St. Jude Medical develops medical technology and services that focus on putting more guidance into the hands of those who treat cardiac, neurological and lingering tribulation patients worldwide. The visitors is dedicated to advancing the practice of medicine by reducing gamble wherever workable and contributing to before all outcomes for every patient. Headquartered in St. Paul, Minn., St. Jude Medical employs more than 12,000 people worldwide and has five serious nave areas that include: cardiac throb management, atrial fibrillation, cardiac surgery, cardiology and neuromodulation. Because of more information, please visit http://www.sjm.com.

About the ANS Sectioning of St. Jude Medical

The ANS Segmentation (Advanced Neuromodulation Systems) became a part of St. Jude Medical in 2005. The ANS Classification is an innovative technology number one dedicated to the mould, development, manufacturing and marketing of implantable neuromodulation systems to rebuild the je sais quoi of spark of life for people suffering from disabling chronic sorrow and other on a tightrope organization disorders (http://www.ans-medical.com).

Forward-Looking Statements

This scuttlebutt release contains forwards-looking statements within the substance of the Unsociable Securities Jacket Refit Turn of 1995 that involve risks and uncertainties. Such nurse along-looking statements file the expectations, plans and prospects for the Performers, including quiescent clinical successes, anticipated regulatory approvals and approaching produce launches, and projected revenues, margins, earnings, and vend shares. The statements made by the Companionship are based upon management’s current expectations and are topic to perfect risks and uncertainties that could ideal realistic results to differ seriously from those described in the forward-looking statements. These risks and uncertainties include superstore conditions and other factors beyond the Company’s lever and the risk factors and other cautionary statements described in the Company’s filings with the SEC, including those described in the Jeopardy Factors and Cautionary Statements sections of the Company’s Annual Turn up on Manufacture 10-K filed on February 27, 2008. The Players does not determine to update these statements and undertakes no loyalty to any bodily to provender any such update under any circumstance.

ANS Division of St. Jude Medical

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Study provides guidelines for treatment of juvenile idiopathic arthritis

Written on March 5, 2010 – 7:03 pm | by gabonshort

International study provides physicians with guidelines for the treatment of juvenile idiopathic arthritis and highlights desperate straits for individualized unwavering be fond of-

A study published by the Cleveland Clinic and The Infirmary payment Shocking Children (SickKids) provides the medical community for the win initially epoch with peculiar to guidelines as regards treating juvenile idiopathic arthritis (JIA), previously known as juvenile rheumatoid arthritis (JRA), a condition that affects approximately one in every 1,000 children. This study is publishing in the October 4 edition of the Journal of the American Medical Link (JAMA). JIA is characterized by the inflammation of joints. The initiation of the fit out typically occurs before the age of 16 and likely results from a claque of genetic and environmental factors. Although there is no cure for JIA, targeted treatment has been shown to make progress symptoms significantly.

“It is vital that parents and caregivers not assume that the symptoms of arthritis are absolutely growing pains,” said Dr. Ronald Laxer, co-author of the study, depravity president, Clinical and Visionary Affairs and staff rheumatologist at SickKids and a professor in the Rely on of Paediatrics at the University of Toronto. “The most common procedure of adolescent idiopathic arthritis affects approximately a woman in a 1,000 Canadian children and if left side untreated can result in suggestive developmental cost to the bones, joints and muscles.”

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The five most communal types of JIA are oligoarthritis, which accounts for 50 per cent of cases and involves the swelling of less than five joints; polyarthritis, with swelling of more than five joints; systemic arthritis, characterized by high fevers and a rash with swelling of other organs in addition to joints; enthesitis-related arthritis, which may affect the spine and hips; and psoriatic arthritis, where children have psoriasis in addition to swollen joints.

Dr. Laxer and Dr. Philip D. Hashkes of the Cleveland Clinic examined more than 279 clinical studies undertaken between 1966 and 2005 to identify the most effective practices for treating the five most common types of JIA, a disability whose cause is not known.

These findings served as the basis for the guidelines published in the JAMA and could ease divers general paediatricians and arthritis specialists (rheumatologists) happier determine how to treat their patients. To date, a clear approach for treating the varied forms of the disease has not existed, undeterred by many advances in the treatment of JIA.

“Treatment on the side of JIA has come a long way over the last 15 years, however, there has not been a set of treatment guidelines based on patient symptoms,” said Dr. Hashkes the study’s principal investigator and a rheumatologist and immunologist in the Cleveland Clinic’s Department of Rheumatic Diseases. “The guidelines in the JAMA study summarize the current evidence-based medical practices for JIA and forearm physicians with a clear-eyed sound out for treating the various subtypes of the virus. By examining a patients’ symptoms physicians can clinch the model of arthritis they have and what approach is most appropriate for treating their condition.”

The Sanatorium for Far-out Children, associated with the University of Toronto, is Canada’s most research-focused convalescent home and the largest centre dedicated to improving children’s health in the outback. Its mission is to prepare for the win out over in kids-centered, compassionate anxiety, to lead in scientific and clinical advancement, and to do the next generation of leaders in child health. For more information, please visit http://www.sickkids.ca.

Chelsea Gay, Civic Affairs, Sick Kids Asylum
chelsea.gay@sickkids.ca
416-813-5045
University of Toronto
http://www.utoronto.ca

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Trends In Prescription Medication Sharing Among Reproductive-Aged Women

Written on March 3, 2010 – 12:43 pm | by gabonshort

Borrowing and sharing of prescription medications is a importance medical and public health concern. A survey of nearly 7,500 women of reproductive ripen found that this is common practice bulk more than one-third of this folk, according to a report published online ahead of print in Journal of Women’s Health, a lord-reviewed record book published by Mary Ann Liebert, Inc. The paper is accessible free online at http://www.liebertonline.com/doi/pdfplus/10.1089/jwh.2007.0769

A survey designed to delineate patterns of prescription medication borrowing and sharing among many groups of adults revealed that women of reproductive age (18-44 years) are more proper to report this conduct (36.5%) than are other old women (19.5%). In the overall survey of more than 25,000 women and men, 28.8% of women and 26.5% of men reported at any time borrowing or sharing prescription medications.

In a distribute entitled “Prescription Medication Borrowing and Sharing centre of Women of Reproductive Age,” Emily Petersen, Sonja Rasmussen, Katherine Daniel, Mahsa Yazdy, and Margaret Honein, from the Centers in the service of Disease Control and Prevention (CDC, Atlanta, Georgia) and Oak Crest Institute in requital for Proficiency & Training (Oak Top edge, Tennessee), report that allergy medications (43.8%) and agony medications (42.6%) were the types of drugs most commonly borrowed or shared by reproductive-aged women.

The authors underscore some of the risks involved in using another person’s recipe drugs, including unanticipated side effects, complications of incorrect exploit, drug-drug interactions, antibiotic resistance, and risk of addiction. Of talented importance in requital for reproductive-aged women is the gamble of teratogenic effects on a developing embryo or fetus if the women were to happen to pregnant while taking the medication.

“This study confirms what many health vigilance providers suspect,” says Susan G. Kornstein, MD, Editor-in-Chief and Executive Principal of the Virginia Commonwealth University Initiate for Women’s Robustness, in Richmond, VA. “It is clear that patients shortage to be counseled up the potential risks of sharing and borrowing medications, especially if they are women of reproductive time.”

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Article adapted by Medical News Today from queer fish prod unfetter.
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Paper of Women’s Fitness is a core multidisciplinary tabloid dedicated to the diseases and conditions that waylay greater risk for or are more prevalent lot women, as ooze as diseases that largesse differently in women. The Journal covers the latest advances and clinical applications of further diagnostic procedures and salutary protocols by reason of the prevention and management of women’s healthcare issues. Annual of Women’s Health is the Official Journal of the American Medical Women’s Camaraderie (AMWA; http://www.amwa-doc.org/).

Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media circle known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical delve into including Obesity Top brass, Breastfeeding Pharmaceutical, Thyroid, Metabolic Syndrome and Tied up Disorders, and Diabetes Technology and Therapeutics. Its biotechnology dealings periodical, Genetic Engineering & Biotechnology News (GEN), was the first in its field and is today the industry’s most widely understand pronouncement worldwide. A complete heel of the firm’s 60 journals, books, and newsmagazines is available at http://www.liebertpub.com/

Mary Ann Liebert, Inc. 140 Huguenot Street, New Rochelle, NY 10801 http://www.liebertpub.com/

Source: Vicki Cohn

Mary Ann Liebert, Inc./Genetic Engineering News

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Northern Ireland Family Doctors Providing The Best Care In The UK

Written on February 28, 2010 – 4:18 pm | by gabonshort

Northern Ireland’s GPs have topped the polls another year game in the provision of quality care for their patients. Figures released today, Friday 19th September 2008, by the DHSSPS display that local GPs are providing the to the fullest extent attend to in the UK.

Commenting on today’s disclosure, Dr Brian Dunn, Chairman of the BMA’s GPs Council in Northern Ireland, said: “I am enchanted and proud to see these results because they not alone reflect the great utility being given to patients here but also the wholeheartedness and commitment of GPs in providing that service.

“Patients be paid the identical attribute care right across Northern Ireland. Irrespective of where you live, the Status & Outcomes Framework applies and patients rightly receive the same access to treatment whether they reside in a badly off area or a more prosperous one.”

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The Quality and Outcomes Framework was introduced in April 2004 as part of the untrained national GP contract. It covers four areas of outstanding care - the clinical, the organisational, the valetudinarian live and additional services.

The clinical area right away covers the treatment of patients suffering from illnesses and diseases such as asthma, cancer, chronic kidney disease, chronic obstructive pulmonary affliction, coronary sympathy infection, dementia, depression, diabetes, epilepsy, soul failure, hypertension, hypothyroidism, mental salubrity, stroke and fugacious ischaemic attacks. Also, those with knowledge disabilities, those hardship from chubbiness or requiring help to stop smoking, and patients who want palliative care.

The patient experience is based on surveys carried out from the beginning to the end of the year. Northern Ireland figures this year show a 100% patient satisfaction rating.

Dr Dunn continued: “GPs are working hard in targeting the diseases that kill and which previously were at best treated in the hospital sector. Heart disease, cancer, kidney disease. They also treat a Brobdingnagian group of other illnesses including asthma, diabetes, embolism, depression and dementia.

“Northern Ireland unfortunately has a jolly tainted rate of heart disease but working as we are now we hope to see a reduction in this particular killer in future years.

“It is also very pleasing and encouraging to see that our patients value their shire general practice so highly. In the past the the better of patients would have had to travel time long distances to a sickbay site fit the treatment they now receive in vague practice. This is of particular importance to older patients and those who are chronically ill. It means they don’t have the stress of a make added to their problems and are more confident with the continuity of care which is together to blended technique.”

British Medical Association Northern Ireland
16 Cromac Place
Cromac Wood, Ormeau Road,
Belfast BT7 2JB
http://www.bma.org.uk

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Vagal nerve stimulation, an innovative therapy for depression

Written on February 27, 2010 – 4:53 am | by gabonshort

The Saint Louis University Trim Sciences Center medical team involved in the analysis and maturation of an innovative cure as a service to despondency - vagal nerve stimulation (VNS) - is starting a new clinic for patients who have treatment-against depression.

The vagal nerve stimulator was approved Friday by the Food and Drug Administration for treatment-resistant depression following clinical trials around the United States, including Saint Louis University.

“This important service could dramatically improve the quality of life for some of the sickest patients, patients who had been on seven to 10 medications and continued to be depressed for years,� says Dr. Charles Conway, who researched vagal nerve stimulation and now will lead the Saint Louis University Vagal Nerve Stimulation Clinic.

The small device is implanted in front of the armpit and has leads that run under the skin to the vagal nerve in the neck. It has been used for and is FDA-approved to treat epilepsy as well.

Charles Donovan, who had participated in the clinical research at Saint Louis University and written a book about his experience, says vagal nerve stimulation changed his life.

“I feel giddy that I’ve gone from the depths of despair to a normal life,� he says. “For over 20 years I had tried every available treatment to give me some relief from the unbearable suffering I experienced from chronic depression.

“When I was implanted with the vagus nerve stimulator in April of 2001, I was desperate. I didn’t want to continue to live a life of utter despair. I had absolutely no idea that my life was about to be completely changed.�

Conway was the principal investigator at the Saint Louis University study site, one of 20 sites across the country to participate in a 200-patient clinical trial between 2000 and 2003.

“One of the most rewarding things I’ve done as a psychiatrist is to conduct research that shows we can help people who have lived essentially all of their lives with severe depression get better,� says Conway, an assistant professor of psychiatry at Saint Louis University School of Medicine and a SLUCare psychiatrist. “Dr. George Grossberg, who directs our division of geriatric psychiatry, and I have found the treatment is successful in helping numerous patients who have failed all other existing therapies.

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“Now, with a new treatment option on the horizon, I am excited we will reach more patients through the Saint Louis University Vagal Nerve Stimulation Clinic. These are patients who had given up hope of ever feeling better.�

Richard Bucholz, M.D., director of the division of neurosurgery at Saint Louis University, brings his experience surgically implanting the device during the study to SLU’s Vagal Nerve Stimulation Clinic. He also was involved in studies that led to the FDA’s approval of vagal nerve stimulation to treat epilepsy.

Patients who are interested in the service will receive an initial consultation to see if the treatment is appropriate; a surgical consultation if they are eligible; and follow-up appointments to monitor and adjust the device settings.

http://www.slucare.edu/

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